W98-KITTLESON: The genetics of feline hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a disease of the heart muscle characterized by thickening of the left ventricular walls. The disease may result in heart failure, thromboembolism, and sudden death. The disease in humans is frequently caused by an inherited defect in the gene of a cardiac contractile protein. Clinically, the characteristics of feline HCM are very similar to those in humans with genetic HCM. These findings support the hypotheses that feline HCM is inherited and may be caused by mutations in contractile protein genes. Eight families of domestic cats with HCM have been identified. In a previous Winn-funded study, the investigators examined the largest of the suspect genes for mutations. No abnormalities were identified. In this continuation study, other candidate genes will also be examined. If mutations are found, genetic tests will be formulated to easily and rapidly detect these mutations. (Continuation of grant awarded in 1995.)