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W97-ADDIE: Feline coronavirus excretion

This research project in the United Kingdom is designed to prove how feline coronavirus (FCOV), the virus that causes feline infectious peritonitis (FIP), is spread between pet cats. After only the first year of the planned three-year project, 67 pet cats from 15 households are taking part and exciting preliminary data has been generated. Ultimately, 100 cats will participate. Continuation of this study will provide answers to many important questions and ultimately will enable the formulation of control measures to prevent the infection of cats with FCOV and development of FIP. The researchers have found that some cats excrete virus for long periods and may be the major source of transmissible virus as well as being at high risk of developing FIP. Other cats have been found to stop excreting virus and then start again. This may be because they remain infected but shed virus intermittently or because they become re-infected by other excreting cats in the households. Further investigation of such cats isolated in single cat households with no access to other cats will answer this question. Cats kept in small groups tend to cease excretion of FCOV more rapidly than cats kept in large groups. Further study of a large number of cats as funded here is required to establish whether this trend is statistically significant. (Continuation of a grant awarded in 1996)

Grant ID: W97-ADDIE

Status: Active

Year Funded: 1997

Amount awarded: $15,000

Investigator: Diane D. Addie, BVMS, RCVS, PhD; Oswald Jarrett, BVMS, RCVS, PhD; University of Glasgow, Scotland