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W16-040: Phenotypic characterization of cardiomyopathy in Birman cats – a phase two continuation study

Birman cats are predisposed to multiple types of heart muscle disease, and an inherited basis appears likely. It is currently not clear whether hypertrophic cardiomyopathy (HCM), where the walls of the heart are too thick; restrictive cardiomyopathy (RCM), where the walls of the heart are too stiff; and arrhythmogenic right ventricular cardiomyopathy (ARVC), where the right side of the heart may be replaced by fat and scar tissue represent 3 different diseases with 3 different causes, or whether these cardiomyopathies are part of the spectrum of one disease with one genetic cause. The aim of this second phase study is to conduct genetic testing on 18 genes associated with cardiomyopathy in humans in order to look for possible mutations that might be responsible for cardiomyopathy in Birmans. If successful, this would lead to a genetic test for cardiomyopathy in Birman cats. (Birman Heart Disease Study)

Grant ID: W16-040

Status: Active

Year Funded: 2016

Amount awarded: $10,812

Investigator: Virginia Luis Fuentes, VetMB, PhD, DACVIM, DECVIM; Royal Veterinary College, University of London