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W16-034: Evaluation of DNA variants associated with hypertrophic cardiomyopathy in the Persian cat

Hypertrophic cardiomyopathy (HCM) is the most common heart disease in the cat. Genetic mutations for HCM have previously been identified in both the Maine Coon and Ragdoll breeds. The identification of the genetic mutation for the disease in these breeds has allowed for the development of a genetic test which can be used for pre-breeding screening purposes. Whole genome sequencing has resulted in the identification of multiple DNA variants that are only found in HCM affected Persian cats and not in a population of normal healthy cats. The purpose of this study will be to sort through these variants to identify the Persian HCM mutation, allowing for improved breeding recommendations and how to eventually treat affected pet cats. (Persian HCM Study)

Grant ID: W16-034

Status: Active

Year Funded: 2016

Amount awarded: $23,531

Investigator: Kathryn Meurs; North Carolina State University