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W16-024: Exploring humoral responses to non-structural proteins of feline coronaviruses

Feline infectious peritonitis (FIP) is a relatively rare but fatal disease of cats. It is a variant of the common feline coronavirus virus (FCoV), which is localized to the intestines and rarely causes serious symptoms. Unlike FCoV, FIP virus is carried in blood to various internal organs, where it replicates in cells called macrophages to cause a systemic infection with a fatal outcome. However, factors that determine this switch are currently poorly understood. Soon after entering the cell, FCoV produces non-structural proteins (nsps), which comprise enzymes necessary for virus replication. This study will examine antibody response by FCoV infected cats to these proteins to determine if there are differences between antibodies produced by cats with different disease outcomes. If so, such differences could become the basis for future development of FIP-specific diagnostic tests and FCoV vaccines. (Bria Fund Study)

Grant ID: W16-024

Status: Active

Year Funded: 2016

Amount awarded: $25,000

Investigator: Magdalena Dunowska, BVsc, PhD; Massey University, New Zealand