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W14-018: Characterizing how FIP virus binds and enters cells

Feline infectious peritonitis (FIP) is a deadly disease of domestic and wild cats. FIP is thought to arise after a feline enteric corona virus (FeCoV) that commonly infects cats and may cause mild diarrhea or no disease at all mutates to become a deadly viral form called feline infectious peritonitis virus (FIPV). The ability of the two virus types to infect different cells in the body is believed to be the difference in their ability to cause disease. Viruses must first bind to the surface of a cell before the virus can enter and replicate within the cell. The binding interactions that allow FIPV to enter into cells are not well understood. The goal of this application is to characterize these interactions and determine some of the molecules involved. Completion of this work will allow a better understanding of how FIPV gains access to cells. Virus entry is where many anti-viral therapies are targeted for prevention of virus infection. The new knowledge gained could lead to development of such therapies against FIP. (Bria Fund Study)

Grant ID: W14-018

Status: Active

Year Funded: 2014

Amount awarded: $24,851

Investigator: Gary Whittaker; Cornell University