Dexmedetomidine is a drug commonly used in cats for its calming and pain‐relieving effects. It is also sometimes used prior to general anesthesia. However, its use is mostly indicated in relatively young, healthy cats, because it produces severe effects on the cardiovascular system. MK-467 is a drug that is expected to prevent the most important of these cardiovascular effects, while preserving the beneficial effects of dexmedetomidine when administered simultaneously. It has been studied in dogs and sheep, but not in cats. The goal is to determine if MK-467 offers a clinically attractive solution with limited negative effects while increasing the tolerance of dexmedetomidine in cats.