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W12-009: Fine mapping for Sphynx cat hypertrophic cardiomyopathy gene

Feline hypertrophic cardiomyopathy (HCM) is the most common cause of heart disease in the adult cat. Affected cats are at risk of sudden death, breathing difficulties or development of a blood clot. Feline HCM is noted to be inherited in the Maine Coon and Ragdoll breeds. In these two breeds, causative genetic mutations have been associated with the development of the disease. This project will continue the study of HCM in the Sphynx breed. A genome wide association study has identified a particular chromosomal area as a region of interest associated with the development of HCM. A close evaluation of this chromosomal region of interest will follow to determine the gene and ultimately the causative genetic mutation. Ultimately, the identification of a genetic cause for HCM in the Sphynx can be used to reduce the prevalence of the disease in this breed and provide information on this disease in many other breeds of cats as well. (Breed Study)

Grant ID: W12-009

Status: Active

Year Funded: 2012

Amount awarded: $24,674

Investigator: Kathryn Meurs, DVM, PhD, DACVIM; North Carolina State University College of Veterinary