Growth of cancer cells is influenced by factors the cells encounter in the local environment in which they live. They require input from without to stimulate internal development and growth, much the way plants may be stimulated to grow when provided with nutrients in the soil in which they are planted. Squamous cell carcinoma (SCC) is a common and deadly oral cancer in the cat for which there are no truly effective therapies. This study is intended to determine the feasibility of depriving feline SCC cells from external stimulation as a strategy to arrest cell growth and contain the tumor. The researchers plan to investigate the potential to use a commercially available protein that attaches to specific entry points on the surface of SCC cells, blocking substances in the tumor “soil” that trigger growth from gaining access to these docking sites. Results from the laboratory-based studies in this project will form the basis for advancing this novel treatment concept into the clinical setting as a new and hopefully improved therapy for cats with devastating oral SCC.