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W11-026: Immunohistochemical Staining of VEGFR, PDGFR, and cKit In Feline Oral Squamous Cell Carcinoma

Oral cancer accounts for 10% of all cancers in the cat, with oral squamous cell carcinoma (OSCC) accounting for about 60% of cases. This disease causes life-limiting clinical signs including excessive salivation, appetite loss, loose teeth, difficulty eating, and weight loss. OSCC is a devastating disease to encounter for the feline patient and owner. Further, it is a frustrating disease for the clinician, since this cancer responds poorly to therapy and no major advancements have been made in treatment despite continued research. Receptor tyrosine kinases (RTK’s) are a class of receptors on the surface of cells that, when activated, control a variety of normal cell functions and are involved in the development of many tumor types. Staining of cells can be performed to determine if these receptors are present at normal levels. Researchers will perform staining of fifteen previously taken feline OSSC biopsy samples to determine the level of these receptors in the cells. Tyrosine kinase inhibitors are a class of drugs new to veterinary medicine. If these receptors are over-expressed in feline OSSC samples, it may be possible to use this new class of drugs for treatment of this disease.

Grant ID: W11-026

Status: Active

Year Funded: 2011

Amount awarded: $9,097

Investigator: Evan Sones, DVM, Medical Oncology Resident. Annette N. Smith, DVM, MS,DACVIM, Stephanie Schleis, DVM, DACVIM (Oncology), Calvin Johnson, DVM, PhD, DACVP, Auburn University