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W08-015: Molecular evaluation of the feline myosin binding protein C gene in Siberian cats with familial hypertrophic cardiomyopathy

Feline hypertrophic cardiomyopathy (HCM) is the most common cause of heart disease in the adult cat. Affected cats are at risk of sudden death, breathing difficulties or development of a blood clot. Increasingly, feline HCM is noted to be inherited, with examples reported in the Maine Coon, Ragdoll, British Shorthair, and Siberian cat, among others. Dr. Meurs has previously demonstrated that HCM is associated with a mutation in the myosin binding protein C gene in the Maine Coon and the Ragdoll cat.

The Siberian cat also has an inherited form of the disease. Given the importance of the myosin binding protein C gene in both Ragdolls and Maine Coon cats with HCM, it is possible that a mutation in this gene, but perhaps in a different region, is associated with the development of HCM in the Siberian. The objective of this study is to evaluate the DNA of this gene in Siberian cats for a causative mutation. (Ricky Fund) (Breed Fund)

Grant ID: W08-015

Status: Active

Year Funded: 2008

Amount awarded: $12,988

Investigator: Kathryn M. Meurs, DVM, PhD, DACVIM; Washington State University