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W08-004: Molecular basis of feline coronavirus pathogenesis and development of FIP in cats, Phase One

Feline infectious peritonitis (FIP) is a deadly disease of cats, caused by a virus infection. The virus normally resides in the gut of the cat, but can mutate and so infect the immune system of certain cats. Based on an analysis of the genome sequence of different viruses, it is proposed that key changes in the surface protein of the virus make it more efficient at infecting the cells of the immune system. Dr. Whittaker proposes to perform laboratory-based experiments using gut and immune system cells, to define the differences between the different viruses. Our work will characterize the changes that occur in the virus surface protein and will allow a more detailed understanding of the devastating disease of cats known as FIP, for which there remains no effective treatment. (Bria Fund Study)

Grant ID: W08-004

Status: Active

Year Funded: 2008

Amount awarded: $15,000

Investigator: Gary R. Whittaker, PhD; Cornell University