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W07-021: Molecular characterization of feline COX-2 and expression in mammary cancer

Mammary tumors are among the most common neoplasms in cats. Evidence indicates that cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the biosynthesis of prostaglandins, plays a role in mammary tumorigenesis in humans and dogs. However, currently available information about the expression of COX-2 in feline mammary cancer is very limited and conflicting. Moreover, the primary structure of feline COX-2 has not yet been characterized. Therefore, the objectives of this proposal are to characterize the structure of feline COX-2 and to study its expression in mammary adenocarcinomas. Our hypothesis is that feline mammary adenocarcinomas overexpress COX-2. More specifically, this project will address two objectives: 1) to characterize the primary structure of feline COX-2, and 2) to determine the expression of COX-2 in feline mammary cancer. Information gained from these studies will help develop tools that will be used in future investigations aimed at exploring the regulation of COX-2 in feline normal and cancerous cells. It is expected that a better understanding of the fundamental mechanisms involved in prostaglandin synthesis in feline mammary cancer will lead to innovative strategies for the prevention and treatment of this widespread and deadly disease in cats. (Breed Study)

Grant ID: W07-021

Status: Active

Year Funded: 2007

Amount awarded: $15,000

Investigator: Monique Doré, DVM, MSc, PhD, DACVP; University of Montreal