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W02-031: Association of Helicobacter Species with Feline Cholangitis/Cholangiohepatitis Complex

Inflammation of the liver (hepatitis) is a common disease in cats, but in most cases, the underlying cause of the inflammation is not discovered. Understanding the causes of feline hepatitis would be useful to improve treatment and prevention strategies. Inflammatory liver disease of cats shares some features with liver inflammation in other species caused by infection with a type of bacteria known as Helicobacter. Helicobacter is common in the stomach and intestine, and the researchers are going to try to determine whether cats with inflammatory liver disease have evidence of liver infection with Helicobacter. Since this organism is difficult to grow, and can be difficult to see on examination of liver biopsies, they are going to use the polymerase chain reaction (PCR) test to identify Helicobacter in biopsy specimens from cats with hepatitis and with another liver disease called hepatic lipidosis (fatty liver). They expect to find evidence of Helicobacter in liver samples from cats with liver disease, but not in liver samples from cats with hepatic lipidosis.

Grant ID: W02-031

Status: Active

Year Funded: 2002

Amount awarded: $14,918

Investigator: Rance Sellon, Katrina Mealey, Washington State University