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MT12-009: Gene Identification for Mediastinal Lymphoma in Oriental and Siamese Type Cats

Lymphosarcoma (LSA, lymphoma) is the most common cancer of cats worldwide. All breeds are susceptible, as are large felids such as the lion, tiger and cheetah. This cancer is also one of the most common cancers in dogs and people. Young cats of the Siamese and Oriental breeds are susceptible to a novel form of LSA; in these breeds, the cancer occurs early (generally when cats are young adults in the prime of their life), and the cancer is situated at the front of the chest (in the cranial mediastinum). LSA in this cohort of cats seems different to other forms of LSA in (i) being unassociated with retroviruses (FIV and FeLV), and (ii) having greater sensitivity to chemotherapy agents (which means many affected cats can be successfully treated using sequential multi-agent chemotherapy). Previous studies funded by the Cat Health Network have helped localize a critical suspect gene to cat chromosome D1. A gene in this region is significantly suspected of being involved with the Oriental cat LSA. Critically, by determining the gene(s) responsible for this type of cancer in Siamese/Oriental cats, a PCR test to identify carriers can be developed, and thereby prevent the next generation of Siamese and Oriental shorthairs developing LSA. Cats used in this study might also prove useful in future studies of genetic conditions commonly seen in Siamese and Oriental cats, such as hepatic amyloidosis. This gene could then be analyzed in other cats with other forms of lymphosarcoma to determine if genetic markers can identify risk.

Grant ID: MT12-009

Status: Active

Year Funded: 2012

Amount awarded: $19,482

Investigator: Leslie Lyons, PhD, School of Veterinary Medicine, University of California, Davis