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MT12-003: Longitudinal evaluation of effects of mesenchymal stem cells in feline chronic allergic asthma: Phase II first part

This study is a continuation of research previously funded by Winn Feline Foundation. Asthma is a common breathing disorder in cats, decreasing quality of life and sometimes causing death. Currently asthma is managed using steroids, which have many unpleasant side effects or may not be able to be given to cats with concurrent diseases like diabetes. Importantly, they only suppress inflammation and do nothing to reverse the underlying abnormal immune response that triggers the asthmatic syndrome. Thus there is a need for new safe and effective treatments for feline asthma. Pilot data from Phase I research indicates that stem cells can be administered safely and alter some aspects of the immune response initially after administration. Other exciting data from Phase I of the study suggests the most dramatic response to stem cell therapy occurs months after administration. This study will look at long term effects of stem cells on the key features of asthma, which include airway inflammation, airway constriction and structural changes.

Grant ID: MT12-003

Status: Active

Year Funded: 2012

Amount awarded: $10,000

Investigator: Carol Reinero, DVM, DACVIM, PhD, Associate Professor and Director, Comparative Internal Medicine Laboratory, University of Missouri