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MT07-005: Oxidative stress and antioxidant therapy in cats with renal failure

Chronic renal failure (CRF) is a common disease of aging cats. The majority of current therapies are non-specific, directed toward controlling clinical consequences of the disease such as nausea, dehydration and decreased appetite. Some of the current treatments are potentially problematic, such as using human recombinant erythropoietin to counter the cat’s anemia, which puts the patient at risk for developing autoantibodies and transfusion dependency. Oxidative stress, the imbalance between pro- and anti-oxidants, is thought to play a key role in the progression of CRF and the complications seen in human renal failure patients. Despite the importance of oxidative stress in patients with CRF, thus far there is only a single study looking at the effect of supplementing CRF cats with antioxidants (vitamins), and it proved to be beneficial. This study is designed to examine the key components of the cat’s antioxidant defense system in this disease. A variety of measures of oxidative stress will be studied, as well as clinical parameters such as body weight and blood pressure. If successful, this study would lay the foundation for deciding on the most appropriate antioxidant supplementation, allowing veterinarians to offer an effective treatment for CRF in cats.

Grant ID: MT07-005

Status: Active

Year Funded: 2007

Amount awarded: $10,979

Investigator: Craig B. Webb, PhD, DVM; Colorado State University