Tritrichomonas foetus (TF) causes chronic diarrhea in cats. Limited treatment options and increasing resistance support investigation of alternative treatments. We are currently pursuing the development of novel drugs to treat feline trichomonosis. Alongside such advances, many cat owners desire complementary approaches including “natural” medications to ameliorate their cat’s diarrhea. Moreover, a multi-targeted approach to treatment is more likely to result in success. There is evidence to suggest that bacteria play an important role in feline TF infection. Thus, targeted manipulation of feline intestinal bacteria by probiotics represents a promising new direction for feline trichomonosis treatment.