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W18-010: Are interferon-gamma polymorphisms a risk factor in FIP development – a large cohort study

Feline infectious peritonitis (FIP) is a common cause of death in cats, particularly those that are less than two years of age. FIP is an unfortunate complication of infection with feline coronavirus, a common virus with a worldwide distribution. Recently, differences in the genes encoding for parts of the immune system have been suggested as risk factors for death due to FIP in pedigree cats. Similar data are not available for non-pedigree cats. In this study a rapid, accurate test for the genetic differences in question would be designed and used to determine whether there is an association between these genetic differences and FIP as the cause of death in a cohort of non-pedigree cats (Bristol-Zurich FIP Consortium in collaboration with University of Liverpool Diagnostic Laboratory). This test would also be applied to a large cohort of non-pedigree cats recruited into the Bristol Cats study to determine how common these genetic differences are in the general cat population. Such data would increase our knowledge as to why FIP affects some cats, but not others. Furthermore, as non-pedigree cats are increasingly used as ‘out-crosses’ in pedigree breeding programs, it is important to determine whether this is something that should be factored into the screening process.

Grant ID: W18-010

Status: Active

Year Funded: 2018

Amount awarded: $6,400

Investigator: Emi Barker, BVSc, PhD, DACVIM, ECVIM and Christopher Helps, BVSc, PhD