Hagman R, Karlstam E, Persson S et al: Plasma PGF(2alpha) metabolite levels in cats with uterine disease, Theriogenology 72:1180-87, 2009.
In many species of animals, uterine disease causes increases in levels of prostaglandin F2alpha, and this can be evaluated by measuring plasma levels of a metabolite called PGFM. In dogs, plasma PGFM levels are associated with the severity of uterine disease and the systemic inflammatory response syndrome (SIRS). SIRS is a serious inflammatory state affecting the whole body, often associated with sepsis. The objectives of this study were to investigate PGFM levels, the presence of SIRS, and clinical and laboratory parameters in cats with uterine disease. In total, 16 cats with uterine disease were evaluated (7 with pyometra, 7 with cystic endometrial hyperplasia (CEH), 2 with mucometra) as well as 14 healthy control cats. Cats with pyometra had higher PGFM levels than healthy cats, and cats with CEH had lower PGFM levels than healthy cats. Systemic inflammatory response syndrome was present in 85% of the cats with pyometra, as well as in one cat with mucometra and one cat with CEH. Further investigation of the role of the SIRS and sepsis in cats with pyometra is needed. [SL]