Newbury S, Moriello KA, Kwochka KW et al: Use of itraconazole and either lime sulphur or Malaseb Concentrate Rinse® to treat shelter cats naturally infected with Microsporum canis: an open field trial, Vet Dermatol 22:75, 2011.
Dermatophytosis (ringworm) is an important skin disease in cats because it is highly contagious and has a zoonotic potential. This disease can be a problem in shelters, especially because of the effect on the most adoptable population in an animal shelter: kittens and young cats. The authors performed an open, non-randomized study of 90 cats with severe dermatophytosis. The cats were treated with 21 days of oral itraconazole at 10 mg/kg and one of three topical antifungal rinses applied twice weekly: lime sulphur (LSO); reformulated lime sulphur with an odor-masking agent (LSR); or a 0.2% miconazole nitrate and 0.2% chlorhexidine gluconate rinse (MC). Weekly examinations were performed along with monitoring of fungal cultures for response to therapy. The cats were not prevented from licking the rinse solutions and none developed oral ulcerations. The study concluded that LSO, LSR, and MC are options for adjunct topical antifungal therapy. LSO was found to result in a significantly shorter number of treatment days than MC or LSR. When a shelter has limited facilities and room for treatment of cats, LSO may be the best option for topical treatment. [VT]
Diesel A, Verbrugge M, Moriello KA: Efficacy of eight commercial formulations of lime sulphur on in vitro growth inhibition of Microsporum canis, Vet Dermatol 22:197, 2011.