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Treatment of Idiopathic Cystitis

Wallius, B.M. and A.E. Tidholm, Use of pentosan polysulphate in cats with idiopathic, non-obstructive lower urinary tract disease: a double-blind, randomised, placebo-controlled trial. J Feline Med Surg, 2009. 11(6): p. 409-12.

One common clinical entity in cats is idiopathic feline lower urinary tract disease (iFLUTD). Various treatments, including glycosaminoglycans (GAGs) such as pentosan polysulphate (PPS), have been advocated. However, few treatments have been investigated by well-controlled clinical trials. This study compared the use of PPS in iFLUTD compared to placebo. Eighteen cats were included in the study with 9 cats given PPS and 9 cats given placebo. Evaluations were performed at 5 and 10 days, 2 weeks, as well as at 2, 6, and 12 months. This study showed that in the majority of cats (89%) with iFLUTD, clinical signs resolved spontaneously and the frequency of recurrent clinical signs were low. There was no statistically significant difference between the group of cats treated with PPS and the placebo group in the short-term and long-term followup. Based on these results, the authors could not recommend PPS for use in iFLUTD. Also in this study, seven cats (39%) of the group were given NSAID therapy for 1 to 4 days after onset of signs. Again, the authors did not consider NSAID therapy beneficial in the short term in this population of cats. [VT]
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Related Articles:
Gunn-Moore, D. and C. Shenoy, Oral glucosamine and the management of feline idiopathic cystitis. J Fel Med Surg, 2004. 6(4): p. 219-226.
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Buffington, C.A., et al., Clinical evaluation of multimodal environmental modification (MEMO) in the management of cats with idiopathic cystitis. J Feline Med Surg, 2006. 8(4): p. 261-8.
>> PubMed Abstract