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Survival of Cats with Kidney Disease

Boyd, L. M., C. Langston, et al. (2008). “Survival in Cats with Naturally Occurring Chronic Kidney Disease (2000-2002).” Journal of Veterinary Internal Medicine 22(5): 1111-1117.

Up to 20% of cats will be affected with chronic kidney disease (CKD) during their lifetime. The prevalence of CKD increases with age, so that almost 1/3 of cats over the age of 15 years are affected. The disease has unpredictable progression and variable presentation, making it difficult to perform long-term survival studies. The International Renal Interest Society (IRIS) has developed a classification scheme for CKD in dogs and cats that is often used in long-term studies. The purpose of this study was to determine the average survival time for a large populatoin of cats from a facility that sees both first and second opinion cases, and to determine if the IRIS stage at diagnosis and after correction of pre-renal azotemia are associated with survival time. The study population consisted of 211 client-owned cats enrolled between April 2000 and January 2002. Clinical characteristics, clinicopathologic data, and survival times were extracted from the medical records. Kaplan-Meier survival curves were performed to determine survival times. Median survival for cats in IRIS stage IIb at the time of diagnosis was 1,151 days, and was longer than survival in stage III (median 778 days) or stage IV (median 103 days). The researchers conclude that IRIS stage of CKD based on serum creatinine at the time of diagnosis is strongly predictive of survival in cats with naturally occurring CKD.
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Related articles:
Syme, H. M., P. J. Markwell, et al. (2006). “Survival of cats with naturally occurring chronic renal failure is related to severity of proteinuria.” J Vet Intern Med 20(3): 528-35.
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Elliott, J., J. M. Rawlings, et al. (2000). “Survival of cats with naturally occurring chronic renal failure: effect of dietary management.” J Small Anim Pract 41(6): 235-42.
>> PubMed Abstract