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Remission of Diabetes in Cats

Sieber-Ruckstuhl, N. S., S. Kley, et al. (2008). “Remission of diabetes mellitus in cats with diabetic ketoacidosis.” J Vet Intern Med 22(6): 1326-32.

Diabetes mellitus (DM) is one of the most common endocrine disorders in cats. DM in cats appears most similar to type 2 DM in humans, with obesity being a strong risk factor. A serious complication of DM in cats is diabetic ketoacidosis (DKA), a hyperglycemic emergency. While remission has been reported in up to 50% of cats with DM, remission in cats with severe DKA has not been reported. The purpose of this study was to evaluate medical records of cats presenting with DKA with diabetic remission and to compare them with those of cats with DKA without diabetic remission and those of cats with uncomplicated DM and diabetic remission. In this retrospective case review, the records of 12 cats with DKA and 7 cats with uncomplicated DM were analyzed. Of the cats with DKA, 7 experienced remission. These cats had more components of a stress leukogram and had pancreatic disease more often than did cats with uncomplicated DM and diabetic remission. They also had been treated more often with glucocorticoids. The researchers conclude that complete or partial remission of DM in cats presenting with DKA is possible. This finding is important as it may influence the willingness of owners and veterinarians to treat cats presenting with DKA.
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Related articles:
Zeugswetter, F. and M. Pagitz (2008). “Ketone measurements using dipstick methodology in cats with diabetes mellitus.” J Small Anim Pract. [Epub ahead of print]
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Bruskiewicz, K., R. Nelson, et al. (1997). “Diabetic ketosis and ketoacidosis in cats: 42 cases (1980-1995).” J Amer Vet Med Assoc 211(2): 188-192.
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