Pulmonary Fibrosis in a Cat Receiving Lomustine

Skorupski, K. A., A. C. Durham, et al. (2008). “Pulmonary fibrosis after high cumulative dose nitrosourea chemotherapy in a cat.” Veterinary and Comparative Oncology 6(2): 120-125.

Lomustine (CCNU) is an alkylating nitrosourea chemotherapy drug. In feline medicine, it has been used for cutaneous lymphoma and mast cell tumors. Neutropenia and thrombocytopenia are known complications, so close monitoring of blood cell parameters is necessary during treatment. In this case report, a cat diagnosed with alimentary lymphoma did poorly on several chemotherapeutic regimes. However, a long-term remission was achieved with lomustine and corticosteroid therapy. After 12 months of therapy, the cat died after an acute episode of respiratory distress. On post mortem examination, severe diffuse pulmonary fibrosis was identified. The cat had no previous history of pulmonary disease. This is the first report of pulmonary fibrosis following high cumulative dose nitrosourea chemotherapy in a cat.