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Predictors of Feline Kidney Disease

Jepson, R. E., D. Brodbelt, et al. (2009). “Evaluation of predictors of the development of azotemia in cats.” J Vet Intern Med 23(4): 806-13.

Chronic kidney disease (CKD) often afflicts geriatric cats, with prevalence rates of 15% reported. The important factors for development of CKD that could be monitored in cats are not known, and were investigated by these researchers. They followed healthy geriatric cats for 12 months (exams every six months), measuring various clinical parameters and correlated these with development of kidney disease. The study evaluated 118 client-owned cats with an average age of 13 years. All were neutered. Physical exams, blood pressure measurement, and blood and urine analyses were done on all cats. Thirty percent of the cats enrolled developed evidence of kidney disease (azotemia) during the study. Of the parameters measured, only two – increased levels of creatinine (including high normal levels) in the blood and detectable protein in the urine – correlated with development of kidney disease (as evidenced by azotemia). The authors concluded that measurement of protein in the urine is an inexpensive and easy way to monitor aging cats for development of CKD. [MK]
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Related articles:
King JN, Tasker S, Gunn-Moore DA, Strehlau G; BENRIC (benazepril in renal
insufficiency in cats) Study Group. Prognostic factors in cats with chronic kidney disease. J Vet Intern Med. 2007 Sep-Oct;21(5):906-16.
>> PubMed Abstract

Boyd LM, Langston C, Thompson K, Zivin K, Imanishi M. Survival in cats with
naturally occurring chronic kidney disease (2000-2002). J Vet Intern Med. 2008 Sep-Oct;22(5):1111-7.
>> PubMed Abstract