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Pradofloxacin for Feline Infectious Anemia

Dowers, K. L., S. Tasker, et al. (2009). “Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats.” Am J Vet Res 70(1): 105-11.

Mycoplasma hemofelis, formerly known as Hemobartonella felis, is the causative agent of feline infectious anemia. The bacterium is spread through flea bites and causes hemolytic anemia that may result in the death of infected cats. It is believed that most infected cats do not clear the organisms even with appropriate antimicrobial treatment, which most commonly is doxycycline. Pradofloxacin is a new fluoroquinolone antibiotic for veterinary use that appears to have increased effectiveness against many bacteria. In this study, treatment of cats infected with M. hemofelis with doxycycline was compared to low and high doses of pradofloxacin. All treatment regimens were equally effective in improving the clinical condition and blood parameters of infected cats. When assessed by molecular detection for clearance of the organism, both low and high dose pradofloxacin were effective, while none of the doxycycline-treated animals completely cleared detectable organisms. The authors concluded that pradofloxacin not only had anti-M. hemofelis effects, it may be more effective at long term M. hemofelis organism clearance than doxycycline.
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Related articles:
Willi, B., F. S. Boretti, et al. (2007). “From Haemobartonella to hemoplasma: Molecular methods provide new insights.” Vet Microbiol 125(3-4): 197-209.
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Ishak, A. M., K. L. Dowers, et al. (2008). “Marbofloxacin for the treatment of experimentally induced Mycoplasma haemofelis infection in cats.” J Vet Intern Med 22(2): 288-92.
>> PubMed Abstract