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Pathogenicity of Feline Cytauxzoonosis

Brown, H. M., R. D. Berghaus, et al. (2009). “Genetic variability of Cytauxzoon felis from 88 infected domestic cats in Arkansas and Georgia.” J Vet Diagn Invest 21(1): 59-63.

Cytauxzoonosis is a highly fatal tick-borne disease of cats, both exotic and domestic. The causative organism, Cytauxzoon felis, is a relatively new pathogen to the USA. It occurs in the south-central, southeastern, and mid-Atlantic regions. Bobcats are believed to be the natural reservoir, and when domestic cats become infected, a rapid disease course ending in death usually occurs. Recently, cases of survival have been documented in domestic cats. This may be due to different strains of the organism. To investigate this possibility, genetic analysis was done on a total of 88 C. felis isolates from cats in Arkansas and Georgia, 44 of which were from cats that survived infection. This analysis identified three unique parasite genotypes, one of which was associated with survival, referred to as genotype ITSA. Thus, there were genetic differences identified that were associated with outcome of infection.
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Related articles:
Brown, H. M., K. S. Latimer, et al. (2008). “Detection of persistent Cytauxzoon felis infection by polymerase chain reaction in three asymptomatic domestic cats.” J Vet Diagn Invest 20(4): 485-8.
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Haber, M. D., M. D. Tucker, et al. (2007). “The detection of Cytauxzoon felis in apparently healthy free-roaming cats in the USA.” Vet Parasitol 146(3-4): 316-20.
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