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Novel Y chromosome genes in the cat

Winn Funded Research

Murphy, W., A. Pearks Wilkerson, et al. (2006). “Novel gene acquisition on carnivore Y chromosomes.” PLoS Genet 2(3): 0353-0363.

Despite its importance in harboring genes critical for spermatogenesis and male-specific functions, the Y chromosome has been largely excluded as a priority in recent mammalian genome sequencing projects. Only the human and chimpanzee Y chromosomes have been well characterized at the sequence level. Here we used direct cDNA selection to isolate and evaluate the extent of novel Y chromosome gene acquisition in the genome of the domestic cat … We discovered four novel Y chromosome genes [in the cat].
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