Wilkes RP, Kania SA. Use of interfering RNAs targeted against feline herpesvirus 1 glycoprotein D for inhibition of feline herpesvirus 1 infection of feline kidney cells. Am J Vet Res 2009; 70: 1018-25.
Feline herpesvirus causes at least 50% of upper respiratory infections in the cat. While vaccines are available, the virus persists in cat populations and spreads readily from infected to naive cats. As well, chronic disease occurs in latently infected cats. Most antiviral medications approved for a similar virus in people are either too toxic for cats or are only minimally effective. Small interfering RNAs (RNAi) are novel therapies that can be used to inhibit expression of genes of interest. This study evaluated the use of RNAi targeted against feline herpesvirus glycoprotein D in order to inhibit herpesvirus infection of cell cultures. Six chemically produced RNAi constructs were evaluated, and two of them proved highly effective in reducing expression of the target glycoprotein. Treatment of cell cultures with RNAi resulted in inhibition of herpesvirus replication. The researchers were able to show that glycoprotein D is essential for the virus to infect cells, and is a potential new target for antiviral treatment. [SL] >> PubMed Abstract
Related articles: Thiry E, Addie D, Belak S, et al. Feline herpesvirus infection. ABCD guidelines on prevention and management. J Feline Med Surg 2009; 11: 547-55.
Malik R, Lessels NS, Webb S, et al. Treatment of feline herpesvirus-1 associated disease in cats with famciclovir and related drugs. Journal of Feline Medicine & Surgery 2009; 11: 40-48. >> PubMed Abstract
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
