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Meloxicam and Kidney Function in Cats

Goodman, L.A., et al., Effects of meloxicam on plasma iohexol clearance as a marker of glomerular filtration rate in conscious healthy cats. Am J Vet Res, 2009. 70(7): p. 826-30.

This study investigates the effect of therapeutic dosages of meloxicam on the plasma clearance of iohexol in healthy, hydrated, conscious cats fed a sodium-replete diet. Meloxicam is a popular non-steroidal anti-inflammatory drug used in cats, but there are few studies on the effect of this drug on feline kidney function. Plasma clearance of iohexol is used as a marker of renal glomerular filtration rate. Six healthy adult neutered male cats were studied in the masked, randomized, crossover study and were administered either no treatment or meloxicam. The studies were performed before the treatment began (baseline) and on the final day of treatment (5 days later). The results of the study indicated that meloxicam did not measurably alter GFR in healthy, hydrated, conscious cats. Additional studies looking at the effects of NSAIDs on GFR in cats with decreased actual or effective circulating blood volume or with renal disease is needed. [VT]
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Related articles:
Gunew, M.N., V.H. Menrath, and R.D. Marshall, Long-term safety, efficacy and palatability of oral meloxicam at 0.01-0.03 mg/kg for treatment of osteoarthritic pain in cats. Journal of Feline Medicine & Surgery, 2008. 10(3): p. 235-241.
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Lascelles, B.D., et al., Nonsteroidal anti-inflammatory drugs in cats: a review. Vet Anaesth Analg, 2007. 34(4): p. 228-50.
>> PubMed Abstract