Berent, A. C., K. J. Drobatz, et al. (2007). Liver function in cats with hyperthyroidism before and after 131I therapy. J Vet Intern Med 21(6): 1217-23.
Hyperthyroidism is a common endocrine disease of senior cats, and many patients have changes in liver enzymes and other markers of liver function at the time of diagnosis. The clinical significance of these markers of liver damage is unknown. In this study, the liver function of 19 cats with naturally occurring hyperthyroidism was evaluated before and after I-131 therapy. The majority of the cats (15/19) had significant increases in at least one liver enzyme, yet functional testing was normal. All hyperthyroid cats had normal livers on ultrasound examination. All cats responded to treatment with I-131 and all changes in liver enzymes returned to normal. This study supports the conclusion that investigation for liver disease is unnecessary in most cats with hyperthyroidism.
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Archer, F. J. and S. M. Taylor (1996). Alkaline phosphatase bone isoenzyme and osteocalcin in the serum of hyperthyroid cats. Can Vet J 37(12): 735-9.