Belouzard S, Millet JK, Licitra BN, et al. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses 2012;4:1011-1033. [Free, full text]
Coronaviruses are the agents of feline infectious peritonitis, a lethal disease of cats. The entry mechanism of the virus into cells is the subject of much research, as it could potentially be a target for antiviral drugs. This research was performed at the Pasteur Institute in Lille, France and at Cornell University, Ithaca, NY. The investigators have characterized the mechanism and have determined that the spike protein of the virus is important in virus entry. In addition, they have characterized the cell receptor used by the virus for attachment and entry. These findings contribute to the increasing understanding of the mechanism of replication of this important pathogen of cats. [MK]
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To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
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Coronaviruses are the agents of feline infectious peritonitis, a lethal disease of cats. The entry mechanism of the virus into cells is the subject of much research, as it could potentially be a target for antiviral drugs. This research was performed at the Pasteur Institute in Lille, France and at Cornell University, Ithaca, NY. The investigators have characterized the mechanism and have determined that the spike protein of the virus is important in virus entry. In addition, they have characterized the cell receptor used by the virus for attachment and entry. These findings contribute to the increasing understanding of the mechanism of replication of this important pathogen of cats. [MK]