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Helicobacter and Lymphoma in Cats

Bridgeford, E. C., R. P. Marini, et al. (2008). “Gastric Helicobacter species as a cause of feline gastric lymphoma: A viable hypothesis.” Vet Immunol Immunopathol 123(1-2): 106-13.

In humans and other animals, gastric Helicobacter spp. bacteria are associated with chronic inflammation. In this study, the relationship between Helicobacter heilmannii and gastric lymphoma in cats was examined. Gastric specimens were collected via biopsy or at necropsy from 47 pet cats with clinical signs of gastrointestinal disease, such as vomiting and anorexia. The specimens were characterized as gastritis (14/47), lymphoma (31/47), or normal (2/47). Staining for Helicobacter organisms was positive in 29 of the specimens. These tissues were then further examined to determine the Helicobacter species involved. Of the cats characterized as having lymphoblastic lymphoma, 13/17 were positive for H. heilmannii. The association between gastric lymphoma in cats and H. heilmannii infection requires further investigation, especially to evaluate the frequency and strain distribution of H. heilmanni in both well cats and those with gastric lymphoma using prospective studies.
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Related articles:
Priestnall, S. L., B. Wiinberg, et al. (2004). “Evaluation of “Helicobacter heilmannii” subtypes in the gastric mucosas of cats and dogs.” J Clin Microbiol 42(5): 2144-51.
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