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FeLV and FIV Affect Blood Values in Cats

Gleich S, Hartmann K: Hematology and serum biochemistry of feline immunodeficiency virus-infected and feline leukemia virus-infected cats, J Vet Intern Med 23:552, 2009.

Complete documentation of the hematologic and biochemical values in cats naturally infected by feline immunodeficiency virus (FIV) or feline leukemia virus (FeLV) has been lacking. The authors performed a retrospective study of 3,780 client owned cats tested for FIV and FeLV. The objective was to report differences in laboratory values between FIV- or FeLV-infected and non-infected and between FIV- and FeLV-infected cats. Serum activity levels of aspartate transaminase (AST) and glutamate dehydrogenase (GLDH) and serum concentration of glucose were significantly lower, while serum concentrations of total protein (TP) and gamma-globulins were significantly higher in FIV-positive cats compared with negative cats. Results indicated significantly lower PCV, hemoglobin (Hb), red blood cell count (RBC) and platelet counts (PLT) in FeLV-positive cats than FIV- infected and control cats. TP and creatinine concentrations were significantly lower in FeLV-infected cats than in non-infected. FeLV-infected cats were at high risk for the development of cytopenias and hematologic abnormalities are common. Clinicopathologic abnormalities are less frequent in FIV-infected cats. [VT]
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Related Articles:
Hofmann-Lehmann R, Holznagel E, Ossent P et al: Parameters of disease progression in long-term experimental feline retrovirus (feline immunodeficiency virus and feline leukemia virus) infections: hematology, clinical chemistry, and lymphocyte subsets, Clin Diagn Lab Immunol 4:33, 1997.
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Levy JK, Scott HM, Lachtara JL et al: Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity, J Am Vet Med Assoc 228:371, 2006.
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