Feline Large Granular Lymphocyte Lymphoma

Krick, E. L., L. Little, et al. (2008). “Description of clinical and pathological findings, treatment and outcome of feline large granular lymphocyte lymphoma (1996-2004).” Veterinary and Comparative Oncology 6(2): 102-110.

Large granular lymphocytes (LGL) can be found in the blood of healthy animals and usually constitute 10% or less of total circulating lymphocytes. Large granular lymphosarcoma/leukemia is a neoplastic disease of lymphocytes rarely seen in cats and dogs and is a distinct variation of lymphoma. Limited information exists regarding pathological and immunohistochemical descriptions, clinical findings, treatment and survival times in cats. Medical records of 45 cats with LGL lymphoma were retrospectively evaluated. The most common clinical signs were decreased appetite, anorexia, weight loss, lethargy, and vomiting. The mesenteric lymph nodes and small intestine were the most commonly affected organs. One complete response and six partial responses were noted in the 23 cats that received chemotherapy as their initial treatment. Median survival time for cats that were treated was 57 days. Based on these results, feline LGL lymphoma appears to be minimally responsive to chemotherapy and is associated with a grave prognosis.

Related articles:
Roccabianca, P., W. Vernau, et al. (2006). “Feline large granular lymphocyte (LGL) lymphoma with secondary leukemia: primary intestinal origin with predominance of a CD3/CD8(alpha)(alpha) phenotype.” Vet Pathol 43(1): 15-28.
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