Feline caliciviruses causing virulent systemic disease are genetically distinct

Winn Funded Research

Ossiboff, R. J., A. Sheh, et al. (2007). “Feline caliciviruses (FCVs) isolated from cats with virulent systemic disease possess in vitro phenotypes distinct from those of other FCV isolates.” J Gen Virol 88(Pt 2): 506-27.

During the past decade, several outbreaks of severe systemic disease associated with feline calicivirus (FCV) have occurred in the USA and the UK. This new disease has caused high mortality in the affected animals and has been termed virulent systemic (VS)-FCV disease. These results suggest that VS isolates have arisen independently several times since first being described and can spread more efficiently in tissue culture than other isolates when infected at low multiplicity.

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