Winn funded research Kennedy, M. A., M. Abd-Eldaim, et al. (2008). “Evaluation of antibodies against feline coronavirus 7b protein for diagnosis of feline infectious peritonitis in cats.” American Journal of Veterinary Research 69(9): 1179-1182.
Feline infectious peritonitis (FIP) is a lethal, complex, and clinically important disease of cats caused by feline coronavirus (FCoV). FCoV occurs in two biotypes: one that is virulent and causes FIP, and one that is nonvirulent. FIP occurs in an effusive form characterized by pleural effusion or ascites, as well as a granulomatous form that may affect several organs. No consistent genetic difference has been identified that can distinguish all virulent from nonvirulent FCoVs. As a result, antemortem diagnosis of FIP is difficult because no test that is specific and sensitive for the FIP virus is available. It has been suggested that the product of the 7b gene is a virulence factor. If expression of the 7b protein consistently leads to FIP, cats infected with virulent FCoV would be expected to have measurable antibodies against this protein, whereas cats infected with the nonvirulent FCoV would not. This would allow differentiation of cats infected with virulent FCoV from those infected with a nonvirulent strain. The purpose of this study was to determine specific antibody concentrations against the 7b protein in cats with FIP or other diseases and healthy cats. Serum samples from 95 cats submitted for various diagnostic tests as well as 20 samples from specific pathogen free cats used as negative controls were tested for antibodies against the 7b protein. Serum from cats with FIP had antibodies against the 7b protein. However, some healthy cats, as well as cats with other diseases, were seropositive for the 7b protein. The researchers conclude that seropositivity for the 7b protein is not specific for the FCoV virulent biotype or a diagnosis of FIP.
Related articles: Hartmann, K., C. Binder, et al. (2003). “Comparison of different tests to diagnose feline infectious peritonitis.” J Vet Intern Med 17(6): 781-90.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
