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Cyclosporine for Cats with Dermatitis

Wisselink, M. A. and T. Willemse (2008). “The efficacy of cyclosporine A in cats with presumed atopic dermatitis: A double blind, randomised prednisolone-controlled study.” Vet J. Feb 20 [epub]

Most cats with atopic dermatitis are treated with corticosteroids, but there are cases where it would be desirable to avoid this class of drugs due to adverse effects. Cyclosporine is widely used in human and veterinary medicine to treat immunological diseases. In most countries, it is licensed for use in dogs, but not cats. In feline dermatology, cyclosporine has been used to treat eosinophilic granuloma complex, pemphigus, atopic dermatitis, and other disorders. In this randomized, controlled, double-blind study, 29 cats with atopic dermatitis were divided into 2 groups. One group (11 cats) was treated with prednisolone (1 mg/kg daily) while the remaining cats were treated with cyclosporine (5 mg/kg/day) for 4 weeks. Blood samples for serum chemistries and hematology were collected at day 0 and day 28. During the trial, the owners were asked to evaluate the intensity of the pruritus once weekly on a linear analog scale and to record side effects. There was no significant difference between the 2 groups in the amount of remission or the number of cats that improved by >25%. No serious side effects were noted. The authors conclude that cyclosporine is an effective alternative to prednisolone for cats with atopic dermatitis.
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Related articles:
Noli, C. and F. Scarampella (2006). “Prospective open pilot study on the use of ciclosporin for feline allergic skin disease.” J Small Anim Pract 47(8): 434-8.
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Vercelli, A., G. Raviri, et al. (2006). “The use of oral cyclosporin to treat feline dermatoses: a retrospective analysis of 23 cases.” Vet Dermatol 17(3): 201-6.
>> PubMed Abstract