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Clostridium difficile in Hospitalized Cats

Clooten, J., S. Kruth, et al. (2008). “Prevalence and risk factors for Clostridium difficile colonization in dogs and cats hospitalized in an intensive care unit.” Vet Microbiol 129(1-2): 209-14.

Clostridium difficile is the most common cause of hospital- and antimicrobial-associated diarrhea in hospitalized humans. A prospective study of C. difficile colonization in dogs and cats was conducted in a veterinary teaching hospital intensive care unit (ICU). Rectal swabs were taken from patients upon admission to the ICU and every third day of hospitalization until discharge or death. C. difficile was isolated from 73/402 (18%) animals; 69% of isolates were toxigenic. Community-associated colonization was identified in 39/366 (11%) of animals that were sampled at the time of admission, while C. difficile was subsequently isolated from 27 of the remaining 327 (8.3%) animals that had a negative admission swab. Administration of antimicrobials prior to admission and administration of immunosuppressive drugs during hospitalization were risk factors for hospital-associated colonization. Acquisition of C. difficile during hospitalization in the ICU was associated with the development of diarrhea.
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Related articles:
Weese, J. and J. Armstrong (2003). “Outbreak of Clostridium difficile-associated disease in a small animal veterinary teaching hospital.” J Vet Intern Med 17(6): 813-816.
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Madewell, B. R., J. K. Bea, et al. (1999). “Clostridium difficile: a survey of fecal carriage in cats in a veterinary medical teaching hospital.” J Vet Diagn Invest 11(1): 50-4.
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