Diabetes mellitus (DM) is a common endocrine disease in cats and is becoming a model for DM in humans because cats develop a form of the disease similar to the human type-2 DM. Amylin is a normal secretory product of pancreatic beta cells and plays an important role in controlling nutrient fluxes. Amylin is an established therapy along with insulin in human diabetics because it reduces post-prandial glucagon secretion and slows gastric emptying. This study was the first to investigate if amylin reduces plasma glucagon levels in cats. Twelve male domestic shorthair cats were tested using an intravenous arginine test (IVAST), a meal response test (MRT), and an IV glucose response test (IVGTT). A single dose injection of a non-amyloidogenic amylin lowered plasma glucagon levels under all three test conditions. Blood insulin concentrations were also lowered following amylin administration in the IVAST and IVGTT relative to controls. The reduced post-prandial glucagon secretion found with the MRT indicates that amylin may have therapeutic potential in controlling post-prandial nutrient metabolism in diabetic cats. This aspect is considered one of the most significant benefits of the combination insulin-amylin treatment in human diabetics. Therefore, amylin may have a therapeutic potential in diabetic cats and may have a use as an adjunct to insulin in their treatment, reducing the insulin requirement to control glycemia. [VT]
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
